+ What is Rejuvenation Facial Cream?

Hyaluronic Acid: A Key Molecule in Skin Aging

The Key molecule involved in skin moisture in hyaluronic acid(HA) that’s has a unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association, and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are the multilane families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.

DMAE Role in Cosmetic Dermatology

• Mitigation of forehead lines and peri orbital fine wrinkles.

• Improving lip shale and fullness as well as overall appearance of aging skin

• Beneficial trends were noted in the appearance of coarse wrinkles, under-eye dark circles, nasolabial fold, sagging neck firmness.

+ What is Anti-Wrinkle Serum?

Peptides of synthesis are a very new strategy in cosmetic science and technology for at least two reasons:

1. They are small molecules, easily penetrable in the skin,
2. They are able to induce a very specific action because all skin cells (keratinocytes, fibroblasts, nervous cells) have membrane receptors for peptides.

This group of cosmeceuticals includes the Botox-like peptides, represented by acetyl hexapeptide 3 (Argireline) and pentapeptide-3 (Leuphasyl). There is a synergistic effect of Leuphasyl and Argireline when taken together.

GHK-Cu (Copper Tripeptide-1)

GHK as a signal peptide enhancing collagen production and acting as a carrier peptide when complexed with Cu(II). Stimulation of collagen and glycosaminoglycan synthesis in skin fibroblasts. Reverse gene expression to a healthier state. Reparative and anti-aging properties.

LEUPHASYL (Pentapeptide-18 Composed of the sequence H-Tyr-Ala-Gly-Phe-Leu-OH)

Was first reported in 2015. It became one of the most popular active ingredients in anti-aging formulations. It acts like enkephalins, decreasing the ACh secretion in the synaptic cleft. Studies acknowledge its effectiveness in wrinkle reduction.

ARGIRELINE

Argireline is a synthetic peptide that is patterned from the N-terminal end of the protein SNAP-25 and has been shown to reduce the degree of facial wrinkles. It is reported to inhibit vesicle docking by preventing formation of the ternary SNARE complex and by interfering in catecholamine release.

+ What Is GHK-Cu?

The human blood tripeptide GHK possesses many positive effects but declines with age. It improves wound healing and tissue regeneration (skin, hair follicles, stomach, and intestinal linings, and boney tissue), increases collagen and glycosaminoglycans, stimulates the synthesis of decorin, increases angiogenesis, and nerve outgrowth, possesses antioxidant and anti-inflammatory effects, and increases cellular stemness and the secretion of trophic factors by mesenchymal stem cells.

Benefits:

• Improves Wound Healing and Tissue Regeneration (Skin, Hair Follicles, Bones, Stomach, Intestinal Linings, and Liver)
• Increases Collagen and Glycosaminoglycans
• Stimulates The Synthesis of Decorin
• Increases Angiogenesis, and Nerve Outgrowth
• Possesses Antioxidant and Anti-Inflammatory Effects
• The Suppression of Fibrinogen Synthesis
• Activation of the Ubiquitin/Proteasome System (UPS).
• Activation of DNA Repair Genes
• Antioxidant Genes
• Suppression of Insulin and Insulin-Like Genes
• Tissue Repair by TGF Superfamily
• Cancer Controlling Genes

+ What is Nicotinamide Adenine Nucleotide (NAD+)?

Nicotinamide Adenine Nucleotide (NAD+) has emerged as a key regulator of cellular processes that control the body's response to stress. NAO boosters, small molecules that raise NAO+ levels, are now considered to be highly promising for the treatment of multiple diseases and the potential extension of the human lifespan.

Nicotinamide Adenine Dinucleotide (NAD) is one of the most important and interesting molecules in the body. It is required for over 500 enzymatic reactions and plays key roles in the regulation of almost all major biological processes (Ansari and Raghava, 2010). Above all, it may allow us to lead healthier and longer lives.

By modulating NAD+ sensing enzymes, it controls hundreds of critical processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and the time of day.

NAD+ levels steadily fall as we age, leading to a decline in the function of cells and organs. By raising NAD+, NAD+ boosters can have profound effects on the health and survival of mammals. Increases in NAD+ promote cognitive and sensory function, gluconeogenesis in the liver, lipogenesis in adipose tissue, insulin secretion in the pancreas, and insulin sensitivity in muscle. NAO+ also promotes endothelial cell proliferation and protects against cardio- and cerebrovascular disease. NAD regulates immune function and inflammation and protects against acute injury in the kidney. NAO promotes and extends fertility in both males and females, ostensibly by activation of sirtuins.

Benefits:

• Liver Function: Key enzymes in NAD+ signaling pathways are known to protect the liver from fat accumulation, fibrosis, and insulin resistance, which are related to the development of fatty liver diseases, such as NAFLD and NASH.
• Kidney Function: Several lines of evidence indicate that reduced levels of NAD+ in aged kidneys and a corresponding decrease in sirtuin activity are largely responsible for reduced kidney function and resilience with age (Ugur et al., 2015).
• Skeletal Muscle Function: Old mice have increased markers of muscle atrophy and inflammation, as well as impaired insulin signaling, and insulin-stimulated glucose uptake compared to young wild-type mice. Treatment of old mice with NAO+ precursors, such as NR and NMN, dramatically improves muscle function.
• Cardiac Function: NAD+ levels are critical for normal heart function and recovery from injury.
• Endothelial and Vascular Function: Cardiovascular and cerebrovascular diseases contribute to the greatest decline in quality of life after 65 and are directly responsible for about one third of all deaths (Nichols et al., 2014; Ungvari et al., 2010).
• DNA Repair and Cancer: Because NAD+ is involved in so many aspects of cancer biology, from mitochondrial activity to cell survival, there are a variety of ways it could be used in the clinic. The rationale for reducing NAD+ levels in tumors is that they will be less able to repair DNA damage, thereby increasing their sensitivity to chemotherapeutic agents.
• Immunity and Inflammation: There is a growing body of evidence that NAD+ precursors can have anti-inflammatory effects.
• Neuronal Function: The neuroprotective effects of NAD+ precursors were first revealed by a study of the middle cerebral artery (MCAO)-induced ischemia, where treatment with NAM reduced the extent of infarct in Wistar rats (Ayoub et al., 1999; Klaidman et al., 2003; Sadanaga-Akiyoshi et al., 2003), a finding recently replicated by treatment with NMN (Wei et al., 2017a).
• Aging and Longevity: Total NAD+ levels were once considered extremely stable. Recently, however, it has become clear that a steady decline in total NAD+ levels over time is a natural part of life for all species, from yeast to humans (Balan et al., 2008; Belenky et al., 2007; Lin et al., 2004; Massudi et al., 2012; Mouchiroud et al., 2013; Zhang et al., 2016; Zhu et al., 2015). This decline, along with the decreased activity of NAD+ signaling proteins, is believed to be one of the major reasons organisms, including humans, age.

+ What is Glutathione?

Glutathione is an antioxidant produced in cells. It's comprised mostly of three amino acids: glutamine, glycine, and cysteine. Glutathione injections work by clearing the body of toxins and free radicals. When we are exposed to toxins. glutathione is used up faster than it can be produced. Glutathione levels in the body can be reduced by many factors, Including poor nutrition. Environmental toxins, and stress. Its levels also decline with age.

Benefits:

• Reduces Oxidative Stress
• Brighten Skin and Help Improve Skin Tone
• Decrease The Body of Free Radicals and Toxins
• May Improve Psoriasis
• Reduces Cell Damage in Alcoholic and Non-Alcoholic Fatty Liver Disease
• Improves Insulin Resistance in Older Individuals
• Increases Mobility for People with Peripheral Artery Disease
• Reduces Symptoms of Parkinson's Disease
• May Help Fight Against Autoimmune Disease
• May Reduce the Impact of Uncontrolled Diabetes
• May Minimize Respiratory Disease Symptoms

+ What is in the skinny shot and what does it do?

MIC+B12: Sometimes diet and exercise alone won’t cut it; more often than not it is a simple fact that you lack vital nutrients and vitamins in the body. In turn, you can’t shed those excess pounds you’ve been trying to get rid of for so long. To burn fat and build muscle, you need to replenish those essential vitamins and minerals.

Methionine: The essential amino acid works as a deactivating agent. Estrogen and sulfur- containing hormones are kept at bay, and it help defend harmful compounds in our system.

Inositol: The lipotropic is in the Vitamin B family. It works many biological processes, helps break down fat , and can be used in treating PCOS effectively. Other email dysfunctions are often Treated using Inositol as well.

Choline: The essential nutrient is vital for liver functionality, and it helps transport bile and stored fat. Exported fat burns, detoxes and liver, and helps promote healthier weight loss results.

Vitamin B12 (Cyanocobalamin): Normal blood flow, brain functionality, heart and nervous system functions, are all served by the essential vitamin. It also helps fat metabolize, meaning you are going to lose weight more easily.

+ What is GACLIV aka Amino Shots?

GACLIV is a blend of six amino acids: Glutamine, Arginine, Carnitine, Leucine, Isoluecine, And Valine.

Glutamine is one of20 naturally occurring amino acids in the dietary protein. In fact, L-glutamine is the most abundant amino acid in the bloodstream and makes up 30-35 percent of the amino acid nitrogen in your blood.

Arginine is an amino acid that changes into nitric oxide (NO). Nitric oxide is a powerful neurotransmitter that helps blood vessels relax and improves circulation.

Carnitine is an amino acid that benefits energy levels by transporting fatty acids into the mitochondria where they can be burned up and used as fuel. For this reason, many take carnitine as a weight loss supplement to help bump up fat burning.

Leucine is very important it is one of the nine essential amino acids and is important for protein synthesis and many metabolic functions. Leucine contributes to the regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. Leucine also prevents the breakdown of muscle proteins after trauma or severe stress

Isoleucine is part of the BCAA group which are significant to human life and are expressly involved in energy, muscle metabolism, and stress. Isoleucine has various physiological functions, such as assisting wound healing, detoxification of nitrogenous wastes, stimulating immune function, and promoting secretion of several hormones. Necessary for hemoglobin formation and regulating blood sugar and energy levels, isoleucine is concentrated in muscle tissues in humans.

Valine is a branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. L-valine is an essential amino acid, meaning that it is not able to be biosynthesized in the human body. It must, therefore, be obtained through dietary sources.

Benefits:

• Boosts Brain Health
• Promotes Muscle Growth and Decreases Muscle Wasting
• Improves Athletic Performance and Recovery from Endurance Exercise
• Burns Fat and Improves Diabetes
• Fighting Inflammation
• Improving Athletic Performance
• Increasing Immune Function
• Reducing Muscle Pains
• Improving Kidney Function
• Improving Mental Capacity
• Helping Lower High Blood Pressure
• Increases Endurance
• Enhances Weight Loss
• Prevents Muscle Damage
• Rises Up Fat Burning
• Boosts Brain Function
• Regulates Blood Sugar

+ What is Tesamorelin/Ipamorelin?

Tesamorelin Is a 3rd generation GHRH (Growth Hormone Releasing Hormone) stabilized synthetic peptide analogue of the hypothalamic peptide. It stimulates the synthesis and release of endogenous GH, with an increase in the level of insulin-like growth factor.

The released GH then binds with the receptors present on various body organs and regulates the body composition. This regulation is mainly because of the combination of anabolic and lipolytic mechanisms. It has been found that the main mechanism by which Tesamorelin reduces body fat mass was lipolysis followed by a reduction in triglycerides level.

• Muscle Building
• Decrease Triglycerides
• Increase Strength
• Enlarge Muscle Mass Reduce Adipose Tissue (Vat)
• More Instantaneous Recovery Times Post- Injury

+ What Is BPC-157?

BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from the human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including tendon-to-bone healing and superior healing of damaged ligaments. Also, BPC 157 seems to protect organs and to prevent ulcers of the stomach. This peptide is also shown to decrease pain in damaged areas. Those who suffer from discomfort due to muscle sprains, tears, and damage may benefit from treatment with this peptide. It can also help aid skin burns to heal at a faster rate and increase blood flow to damaged tissues.

Benefits:

TENDONS

• Tendon Healing
• Decrease Pain
• Increase Collagen Synthesis
• Quicker Recovery Times Post-Injury

LIGAMENTS

• Wound and Bone Healing
• Decrease Inflammation
• Intestinal Issues
• Protects the Heart

MUSCLES

• Reverse Opioid Polerance
• Enhance GABA Neurotransmission

+ What is CJC-1295?

CJC-1295 is a synthetically produced peptide that can increase your plasma growth hormone levels. Initially, CJC-1295 was developed to treat diseases and medical conditions for patients who had muscle disorders, diseases, and burn victims. CJC-1295 has drawn many individuals like athletes from around the globe for its incredible benefits and minimal side effects to enhance their performance on the field and in the gym.

The primary purpose of CJC-1295 is to boost protein synthesis levels and help fuel the growth of muscle tissues in the body. Many benefits will be derived by users who are incorporating CJC-1295 to their regimen; among these are:

Benefits:

• Decrease Body Fat
• Improve Sleep Quality
• Increase Cognitive Function
• Quicker Recovery Times Post-Injury
• Increased Muscle Mass
• Increase in Strength

It is used alongside Ipamorelin because of the synergistic effects and increased GH release levels. An increase in growth hormone levels. These are naturally released by the pituitary glands, and as your body stops producing the hormone as you age, a supplement, such as Ipamorelin, can naturally help increase those dissipated levels.

If using it with CJC-1295, you can experience a correlation in increased muscle mass levels. With more extended-release periods, more significant results are achievable. So, if you want to gain more muscle mass, or if you just want to increase levels of lean muscle mass, you are going to realize these possibilities when you incorporate the use of Ipamorelin into your daily regimen.

Less downtime. You will recover faster, your body will recuperate more quickly, and you are back on your feet faster. So, you won't experience as much downtime after a tough workout, letting you get back to your regimen faster.

Faster weight loss is achieved. Increase in lean muscle mass, increase in metabolic rate and increase growth hormones, all work together to help you burn more calories, and conversely lose more weight in less time. Your skin, nails, and hair will look better. It can work to help fight the signs of aging, and you are going to look and feel younger. A younger, more jovial appearance is almost instantly realized among users who incorporate Ipamorelin to their workout and diet regimen.

+ What is MOTS-C (Mitochondrial Open Reading Frame of the 125 rRNA-c)?

MOTS-C is a short open reading frame (sORF) 16 amino-acid peptide. MOTS-C has endocrine-like effects on muscle metabolism, insulin sensitivity, and weight regulation. It regulates insulin sensitivity and metabolic homeostasis. Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle. MOTS-C targets the Methionine-Folate Cycle, Increases AICAR levels, and activates AMPK. A well-described role of AICAR is to activate AMPK and stimulate fatty acid oxidation and enhance glucose uptake in the muscle.

MOTS-C has been shown to target the skeletal muscle and enhance glucose metabolism. As such, MOTS-C has implications in the regulation of obesity, diabetes, exercise, and longevity, representing an entirely novel mitochondrial signaling mechanism to regulate metabolism within and between cells.

MOTS-C assists with gene expression and cellular metabolism. It appeared to stimulate glucose utilization by increased glucose clearance. Coordinates cellular glucose, mitochondrial, and fatty acid metabolism.

MOTS-C prevents HFD-induced obesity by increasing energy expenditure, including heat production, improving glucose utilization and insulin sensitivity. Reduced fat accumulation may be a result of robust carbohydrate usage that reduces fatty acid synthesis.

Benefits:

• Regulates Insulin Sensitivity and Maintain Metabolism
• Stimulate Fatty Acid Oxidation
• Enhance Glucose Uptake and Clearance into Muscle
• Stimulate Glucose Utilization
• Coordinates Cellular Glucose, Mitochondrial, and Fatty Acid Metabolism
• Increased Energy Expenditure and Heat Production
• Reduction of Fat Accumulation

+ What is Tetradecyl Thioacetic Acid / Amlexanox??

Tetradecyl Thiacetic Acid, otherwise known as TTA, is what is known as a PPAR-alpha activator. It is an omega-3 fatty acid. PPARa activation can be seen as protecting the body from excess fats. PPARa tends to clear fats from the blood into muscle or liver cells and encourage them to be burnt for energy in these locations. The clearing of fat from the blood cause a drop in lipoproteins and a lowering of LDL cholesterol. The burning of fats causes either fat burning or reduced-fat gain. TTA can also decrease blood pressure and exert an antioxidants effect, the four mechanisms make this a cardioprotective compound. TTA has been shown to reduce body weight gain (primarily by reducing adiposity), provide beneficial effects on insulin resistance and elevated plasma glucose levels, and improve dyslipidemia in pre-clinical models of obesity and diabetes.

Amlexanox, an inhibitor of IKKe and TBK1, was first developed as an anti-inflammatory and anti-allergic drug used to treat asthma in the 1980s in Japan. The inflammatory kinases IKKe and TBK1 are elevated in obesity. Studies have shown that chronic stress triggered by obesity causes inflammation through the activation of the pathway NFKB. This pathway induces genes associated with inflammation and obesity, including TBK1. When TBK1 is activated, it shuts down AMPK, one of the master regulators of energy expenditure, reducing a cell’s ability to burn calories and resulting in fat storage. This is the mechanism by which obesity reduces energy expenditure.

Benefits:

• Weight Loss
• Decrease LDL Cholesterol
• Improve Insulin Resistance
• Decreased the Epididymal Adipose (Fat) Tissue Mass
• Increase Fatty Acid Transport, Uptake and Oxidation
• Lower Blood Pressure
• Reduction in Hemoglobin A1c and Fructosamine
• Cardioprotective

+ What is Exenatide (GLP-1 Agonist)??

Exenatide is a GLP-1 agonist. GLP-1 is a peptide hormone that increases insulin secretion and decreases glucagon secretion from the pancreas 1n a glucose-dependent manner. We know that GLP-ls appear to help suppress appetite. These drugs slow the movement of food from the stomach into the small intestine. As a result. You may feel full faster and longer, so you eat less. These medications mimic the action of a hormone called glucagonlike peptide l. When blood sugar levels start to rise after someone eats, these drugs stimulate the body to secrete more insulin. The extra insulin helps lower blood sugar levels.

Benefits:

• Lower Blood Sugar
• Weight Loss
• Feel Full Faster and Longer
• Suppress Appetite
• Increase Sugar Uptake and Synthesis in Peripheral Tissues

+ What is Thymosin Beta-4?

Thymosin Beta-4 is a protein that consists of 43 amino acids. TB-500 is a synthetic fraction of the protein thymosin beta-4. The main purpose of this peptide is to promote healing. The healing effects of TB-500 have been observed in tendons, ligaments, muscles, skin, heart, and eyes. Thymosin beta-4 is naturally produced in higher concentrations where tissue has been damaged. This peptide is also a very potent anti-inflammatory agent.

Benefits:

• Increased Cells in Healing
• Improves Cell Migration to the Cite of the Injury.
• Soft Tissue Repair-Tendon, Ligament, Muscle Sports, and Athletic Injuries
• Reduces Scar Tissue
• Improves the Mortality Rate
• Significant Repair and Regenerative Properties
• Enlarged Muscle Growth, Muscle Tone, and Muscular Stamina

+ What is MK677 Ibutamoren?

MK-677 is a hormone secretion compound that stimulates the pituitary gland to increase the production of human growth hormone. Ibutamoren is a long-acting, orally active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, imitating the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.

Benefits:

• Increase IGF-1 Levels in As Little as Two Weeks
• Longer REM Sleep and Shorter Sleep Latency
• Increase Fat-Free Muscle Mass
• Decrease Body Fat Percentage
• Stronger Bones
• Improved Endurance
• Increase Nitrogen Levels in The Body
• Reversal of Nitrogen Wasting

+ What is 5-Amino-1MQ?

Nicotinamide-N-methvitransferase(NNMT), is a cytosolic enzyme with newly identified roles in cellular metabolism and energy homeostasis. Studies indicate that this enzyme slows down the process at which our bodies metabolize fat cells. Most people have a hard time losing weight. When this enzyme is elevated, they have a more challenging time trying to lose excess pounds of fat. The extra weight leads to an increase in the NNMT enzyme, leading to slower fat metabolism, leading to excess weight gain. It is a vicious cycle. Research suggests a potent NNMT inhibitor "5-amino 1mq" significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels. These results support the development of small molecule NNMT inhibitors as therapeutics to reverse diet-induced obesity and validate NNMT as a viable target to treat obesity and related metabolic conditions.

Benefits:

• Reduce the Formation of Fat Cells and Size
• Reverse Diet-Induced Obesity
• Increase Fat Metabolism
• Decrease Cholesterol Levels

+ What Is AOD-9604 (Anti-Obesity Drug)?

AD 9604 is a modified form of amino acids 176-191 of the GH polypeptide. Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the GH molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears not to affect growth or insulin resistance. It works by mimicking the way natural Growth Hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified Growth Hormone. Like Growth Hormone, AD 9604 stimulates Lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis (the transformation of nonfat food materials into body fat).

Benefits:

• Reduces Body Fat
• Regulates Fat Metabolism
• Stimulates Lipolysis
• Inhibits Lipogenesis
• Triggers Fat Release